Clonazepam 1mg cannot be bought online through secure digital doorstep routes as a Schedule IV controlled substance requiring a valid EPCS prescription from a DEA-registered US healthcare provider for panic disorder, seizures, or restless legs syndrome; prescription-free digital procurement violates 21 U.S.C. § 841 federal felony distribution laws with up to 20-year imprisonment penalties.
Dosing initiates at 0.25-0.5mg BID titrating to 1mg BID maximum 4mg/day divided under 2025 DEA guidelines, with telemedicine flexibilities expiring December 31, 2025 mandating synchronous HIPAA video PDSS ≥15 confirmation and multi-state PDMP clearance—no doorstep route bypasses EPCS authentication or post-flex in-person initiation across 50 states.
Clonazepam 1mg (GABA-A α2/α3 agonist Ki 0.5nM), Tmax 1-4h, t½ 30-40h active metabolite; black box warnings include 35-45% dependence week 4, opioid respiratory depression OR10, withdrawal seizures 25%—taper 0.125mg weekly 8-12 weeks CIWA-B monitoring; contraindications glaucoma, COPD AHI>30, CYP3A4 inhibitors x3 exposure.
Diagnostic: PDSS ≥15 + 6-month history excluding mimics.
Screening: PDMP clean, C-SSRS negative, stable vitals.
EPCS: #30 tabs 1mg ≤5 refills/6mo signature delivery.
Monitoring: ≥30% PDSS q30d + UDS.
| Incidence | Effect | Risk Factors | Management |
|---|---|---|---|
| 25-45% | Sedation/ataxia | >2mg/day elderly | BID low dose falls protocol |
| 15-30% | Amnesia/depression | >4 weeks | MoCA/PHQ-9 q4w taper |
| 10-20% | Respiratory OR10 | Opioids | Naloxone standby |
| 5-15% | Agitation | PDx | Valproate switch |
| <1% | Seizures | Abrupt stop | Lorazepam rescue |
Secure digital doorstep route constitutes federal felony under Ryan Haight Act—no legal bypass exists.