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 Percocet is considered when non-opioid pain medications are insufficient to relieve moderate to severe pain. It combines oxycodone and acetaminophen, with the oxycodone component acting on the central nervous system to reduce pain perception and acetaminophen enhancing anti-inflammatory effects. Percocet is available in 325 mg, 500 mg, and 650 mg tablet strengths, allowing physicians to tailor treatment based on individual patient needs. Compared to over-the-counter medications like ibuprofen or acetaminophen alone, Percocet provides stronger analgesic effects for acute pain episodes, post-surgical recovery, or severe back or abdominal pain. Because it contains an opioid, it is prescribed for short-term use under strict medical supervision to reduce the risk of dependence, tolerance, and adverse effects. Patients may experience side effects such as drowsiness, constipation, nausea, or dizziness. Proper adherence to dosing schedules and avoiding alcohol or sedatives is essential for safe use. Physicians integrate Percocet into comprehensive pain management plans that may include alternative medications, physical therapy, or lifestyle adjustments to reduce opioid exposure. Educating patients on safe use, dosage differences between 325 mg, 500 mg, and 650 mg tablets, and the importance of monitoring symptoms ensures Percocet is used effectively while minimizing risk. Overall, Percocet is a clinically guided, potent option for managing severe pain when non-opioid therapies are inadequate.