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 Percocet is a combination medication that includes oxycodone and acetaminophen, designed to manage moderate to severe pain effectively. Oxycodone, an opioid, works by binding to specific receptors in the central nervous system to reduce the perception of pain, while acetaminophen enhances this effect by addressing inflammation-related discomfort. Percocet is available in 325 mg, 500 mg, and 650 mg tablet strengths, allowing healthcare providers to tailor the dosage according to the severity of pain and the patient’s medical history. It is primarily intended for short-term use, such as post-surgical pain, severe back pain, gallstone pain, or intestinal pressure. Because it contains an opioid, strict adherence to the prescribed dosing schedule is essential to prevent dependence, tolerance, or other adverse effects. Common side effects include drowsiness, dizziness, nausea, and constipation, while rare but serious effects, such as respiratory depression, require immediate medical attention. Patients are advised to avoid alcohol or sedatives during therapy and follow storage and disposal guidelines to prevent accidental ingestion or misuse. Percocet is often integrated into a comprehensive pain management plan that includes non-opioid medications, physical therapy, and lifestyle adjustments to enhance safety and effectiveness. Patient education is a key component, focusing on safe use, recognizing side effects, and maintaining regular communication with healthcare providers. With responsible use, Percocet tablets in 325 mg, 500 mg, and 650 mg strengths provide clinically guided, effective relief from severe pain.