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 Percocet, a combination of oxycodone and acetaminophen, provides effective relief for moderate to severe pain but can cause side effects that patients should be aware of. The medication is available in 325 mg, 500 mg, and 650 mg tablet strengths, allowing physicians to adjust therapy according to individual needs and pain severity. Common side effects include drowsiness, dizziness, constipation, and nausea. Less common but more serious complications may involve respiratory depression, allergic reactions, or liver damage if acetaminophen is taken in excess. Because Percocet contains an opioid, it is classified as a controlled substance, and patients are advised to follow prescribed dosages carefully. Alcohol, sedatives, and other medications that affect the central nervous system should be avoided while taking Percocet to reduce the risk of serious interactions. Safe storage and proper disposal of unused tablets are essential to prevent accidental ingestion or misuse by others. Physicians closely monitor patients’ responses, adjusting tablet strength—325 mg, 500 mg, or 650 mg—as necessary and providing education on safe use, potential side effects, and when to seek medical attention. By understanding both the benefits and potential risks, patients can use Percocet effectively for severe pain while minimizing complications, ensuring safe and clinically guided pain management.